Liposomal Glutathione – High concentration in reduced form

Liposomal Glutathione (Liposovit^®) (250 mg glutathione) from EssentialSeries is a dietary supplement in vegetable capsules, based on glutathione.

Made exclusively from glutathione in its reduced form (GSH), and encapsulated using an innovative dry liposomal matrix developed by Liposovit^®, this is an optimized presentation designed for those who want to add quality glutathione to their routine, avoiding ineffective formulas or unnecessary extra ingredients. Being protected inside a dry liposomal structure, glutathione keeps its integrity during digestive transit, which helps its optimal absorption.

An advanced formula, focused on the essentials: high-quality reduced glutathione, protected and optimized thanks to Liposovit^® technology.

Why choose reduced glutathione (GSH) over other forms?

Glutathione exists in different forms, with the most notable being reduced glutathione (GSH). This is the predominant form in human cells and the one best suited to the physiological processes involving this nutrient. Its specific structure allows it to remain stable under normal conditions and be compatible with the body's functions.

Unlike oxidized glutathione (GSSG), reduced glutathione is more stable, making it the preferred form when looking for a quality presentation to be used as a dietary supplement.

Also, reduced glutathione is more sensitive to environmental conditions, so its preservation requires specific processes to prevent degradation. This is where technologies like liposomal encapsulation become especially important, as they protect the compound against adverse conditions during its passage through the digestive system.

So, if you want a functionally stable form consistent with glutathione’s natural profile in the human body, the reduced option (GSH) is the right choice.

Liposovit®: A patented liposomal matrix

What is Liposovit®?

Liposovit^® is a patented dry liposomal technology developed to improve protection, stability, and bioavailability of compounds in dietary supplement formulations. Unlike classic liposomal systems in liquid or semi-solid form, Liposovit^® uses a powder approach that encapsulates the ingredient in a solid liposomal matrix, without solvents, ethanol, or extreme pH during the process.

Moreover, Liposovit^® has been developed in Europe under strict quality standards and is patented, which supports its properties, manufacturing method, and stability. We have used, and continue expanding our product catalog with this technology as it has been successfully applied to delicate ingredients, allowing us to formulate capsules containing powder, making them practical and easy to include in any routine.

Advantages over traditional liposomes

Traditional liposomal systems usually come in liquid form, which involves certain limitations in terms of stability, need for refrigeration, and use of additives or preservatives to maintain integrity. Also, they often require solvents like ethanol to keep fluidity or more complex structures to stabilize the encapsulated ingredient.

Liposovit^® offers a more functional approach that solves these issues through a solid, completely dry liposomal matrix that allows maintaining the formulation in capsules without altering the liposomal structure or compromising the protection of the encapsulated compound. This format:

•  Does not require refrigeration or stabilizing agents, allowing the compound’s integrity to be maintained at room temperature.
•  Does not use alcohols or acidic media during manufacturing, preserving the reduced glutathione structure without exposing it to harsh conditions.
•  Avoids unnecessary additional ingredients, keeping a 'clean label' formulation respectful of the compound’s sensitivity.

Optimizing bioavailability without compromising quality

One of the main challenges when formulating glutathione is its sensitivity to digestive environment conditions. Reduced glutathione (GSH), in its free form, can easily degrade in the stomach due to acidic pH and enzyme action, which hinders its absorption and limits its use.

Unlike other methods that require combinations with other ingredients to try to optimize absorption, the Liposovit^® system works autonomously, without needing poorly supported synthetic additives. This allows a formulation aligned with our 'clean label' philosophy, cleaner, focused solely on the main compound and its protective vehicle.

A clean label and transparent formula

At HSN we formulate all our products following clean labeling principles: transparency, simplicity, and real quality. This means each capsule of our Liposomal Glutathione (Liposovit^®) contains only what’s necessary, no superfluous ingredients, no aesthetic fillers, and no additives that distort the essence of the dietary supplement.

We work with a clear vision: to offer advanced and transparent products, without disguising their composition. This commitment is reflected both in the choice of raw materials, using an internationally recognized liposomal patent, and in designing a formula that avoids colorants, preservatives, and allergens, including cross-contamination.

Choosing HSN means choosing transparency, precise labeling, and a formulation where every ingredient has a reason to be. 

Discover HSN’s liposomal products

We present our full catalog of liposomal formulas!

Check them out in our category: Liposomal Nutrients.

References

• Richie, J. P., Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J. S., Schell, T. D., & Muscat, J. E. (2015). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition, 54(2), 251–263.
• Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P. (2017). Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology, 10, 147–153.
• Zeevalk, G. D., Bernard, L. P., & Guilford, F. T. (2010). Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells. Neurochemical Research, 35(10), 1575–1587.
• Kadry, M. O. (2019). Liposomal glutathione as a promising candidate for immunological rheumatoid arthritis therapy. Heliyon, 5(7), e02162.
• Sinha, R., Sinha, I., Calcagnotto, A., Trushin, N., Haley, J. S., Schell, T. D., & Richie, J. P. (2018). Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. European Journal of Clinical Nutrition, 72(1), 105–111.