Sequential Release Melatonin (Melotime™) - 1mg Melatonin

Sequential Release Melatonin (Melotime™) (1mg Melatonin) from EssentialSeries is a dietary supplement in tablet form based on sequential release melatonin.

You’re looking at a next-generation formula developed with patented melatonin under the dual release system Melotime™, designed to support nighttime rest. Unlike traditional forms, this melatonin works in two phases: an immediate release fraction and a sustained release fraction. Each tablet contains 2,2 mg of Melotime™, equivalent to 1 mg of pure melatonin. Formulated without allergens or unnecessary additives.

Enjoy advanced technology that meets the needs of those seeking quality sleep naturally, safely, and backed by science.

Melotime™ Technology: immediate and sustained release

Phase 1: quick start to help fall asleep

This immediate release allows the compound to be quickly available in the body, facilitating its action on melatonin receptors in the central nervous system. As a result, it enhances its most well-known and scientifically supported effect:

This mechanism is especially useful for people who have trouble falling asleep, whether due to stress, screen exposure, irregular schedules, night shifts, or circadian rhythm disruptions. By ensuring rapid absorption of part of the melatonin, Melotime™ helps speed up the transition from wakefulness to sleep naturally, without causing dependence or daytime drowsiness.

Phase 2: sustained release to support nighttime rest

After the initial release, the Melotime™ formulation continues working through a second sustained release phase, thanks to its sequential granulation technology. This phase is designed so that the rest of the melatonin is gradually released throughout the night, staying available in the body for a longer period compared to immediate release forms.

This biphasic pattern doesn’t change melatonin’s mechanism of action but offers an important functional advantage: it helps respect the physiological release profile of natural melatonin, which also occurs progressively from the pineal gland during the night.

This feature is especially relevant for those who experience frequent sleep interruptions or sudden awakenings.

Also, by prolonging melatonin presence in plasma without excessive peaks, this formulation promotes a smoother transition between sleep phases. In short, Melotime™ provides smart chronobiological support, respectful of circadian rhythms and aligned with evidence-based sleep hygiene.

Benefits backed by scientific evidence

Helps reduce the time needed to fall asleep

Melatonin is a substance naturally present in the body, involved in regulating the sleep-wake cycle. Taking it shortly before bedtime in the right amount (like the dose in each tablet of our formula) helps reduce the time it takes to fall asleep¹, making the transition from awake to asleep faster.

This benefit is well documented and makes melatonin an ideal option for people who have trouble falling asleep, whether occasionally or regularly. The Melotime™ sequential release technology enhances this effect by ensuring immediate absorption of part of the melatonin just when the body needs it.

Without causing dependence or morning drowsiness, melatonin is an effective tool, especially well tolerated in its sequential release form to improve sleep onset.

Helps counteract jet lag effects

Changing time zones, especially on long flights east or west, can disrupt the natural sleep rhythm and cause fatigue, insomnia, or a feeling of jet lag. Melatonin, taken at the right time, is the perfect ally to help the body adapt to the new schedule, because:

Each tablet of our formula provides the right dose to achieve this effect, and thanks to its sequential release system, it offers gradual availability of the compound that supports the adjustment of the sleep-wake cycle during travel days.

This effect is especially useful for frequent travelers, professionals on the move, or people sensitive to schedule changes, who want an option to minimize jet lag’s impact on their rest and overall well-being.

Clean label formula: quality in the details

Our formula has been developed with a clean label approach, a hallmark of HSN developments, meaning its formulation is transparent, minimalist, and free of unnecessary additives. Each ingredient has been selected with a single functional purpose, without fillers or compounds that don’t add real value.

The composition is based on just three essential elements:

• Sequential release melatonin (Melotime™), the main ingredient with patented technology
• Microcrystalline cellulose as a natural bulking agent, which allows tablet compression.
• Plant-based coating made from hydroxypropyl methylcellulose and glycerin, which stabilizes the format without adding colorants, lacquers, or synthetic additives.

Who is this product for?

It’s especially recommended for:

• People who have trouble falling asleep, whether due to stress, routine changes, screen use at night, or imbalances in rest habits.
• Frequent travelers who need to quickly adapt to new time zones and minimize jet lag’s impact on their well-being.
• Workers with changing schedules or rotating shifts, whose circadian rhythm is disrupted and need to regulate their sleep-wake cycle.

Frequently Asked Questions (FAQ)

What’s the difference between this melatonin and other conventional ones?

Unlike common fast-acting melatonins, this formula uses Melotime™, a two-phase sequential release technology: it releases part of the melatonin immediately to help fall asleep, and the rest gradually to maintain availability throughout the night.

Is 1mg of melatonin enough to notice effects?

1 mg of melatonin taken shortly before sleeping is enough to help reduce the time needed to fall asleep.

Can I take it if I travel frequently and suffer from jet lag?

This melatonin is ideal to help relieve the subjective feeling of jet lag. To get this effect, at least 0,5 mg is required, and it’s recommended to take it shortly before bedtime on the first travel day and for a few days after arriving at the destination.

Does it cause drowsiness the next day?

When taken at the recommended dose, this melatonin does not cause drowsiness upon waking. Its sequential release is designed to respect the natural sleep rhythm, without residual effects or grogginess the next day.

References

• Zwart, T. C., Smits, M. G., Egberts, T. C. G., Rademaker, C. M. A., & van Geijlswijk, I. M. (2018). Long-term melatonin therapy for adolescents and young adults with chronic sleep onset insomnia and late melatonin onset: Evaluation of sleep quality, chronotype, and lifestyle factors compared to age-related randomly selected population cohorts. Healthcare (Switzerland), 6(1), 23.
• Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders. PLoS ONE, 8(5), e63773.
• Li, T., Jiang, S., Han, M., Yang, Z., Lv, J., Deng, C., … Yang, Y. (2019). Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis. Frontiers in Neuroendocrinology, 52, 22–28.
• Peuhkuri, K., Sihvola, N., & Korpela, R. (2012). Dietary factors and fluctuating levels of melatonin. Food & Nutrition Research, 56(1), 17252.

¹ The beneficial effect is obtained with an intake of 1 mg of melatonin shortly before going to sleep.

² The beneficial effect is obtained with a minimum intake of 0,5 mg, which should be taken shortly before bedtime on the first travel day and for a few days after arriving at the destination.